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The first European to encounter the Mekong was the Portuguese António de Faria in 1540. A European map of 1563 depicts the river, though even by then little was known of the river upstream of the delta. The first systematic European exploration began with the French Mekong Expedition led by Ernest Doudard de Lagrée and Francis Garnier, which ascended the river from its mouth to Yunnan between 1866 and 1868. Their chief finding was that the Mekong had too many falls and rapids to ever be useful for navigation. From 1893, the French extended their management of the river into Laos, establishing French Indochina by the first decade of the 20th century. This lasted until the primary and Second Indochina Wars expelled French from its former colony and defeated US-supported governments. During the wars in Indochina within the 1970s, a major quantity of explosives (sometimes, total barges loaded with army ordnance) sank within the Cambodian part of the Mekong (as well as in the nation's other waterways). Besides being a danger for fishermen, unexploded ordnance additionally creates problems for bridge and irrigation systems building. As of 2013, Cambodian volunteers are being skilled, with the assist of the Office of Weapons Removal and Abatement within the US State Department Bureau of Political-Military Affairs, to conduct underwater explosive removal. The numerous maps of the river basin produced throughout recorded historical past mirror the area's altering human geography and politics. In 1995, Laos, Thailand, Cambodia, and Vietnam established the Mekong River Commission (MRC) to manage and coordinate the use and care of the Mekong.

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