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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as focusing on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized various investigators and had participants from different geographic areas. This type of heterogeneity, which is essential for pragmatic trials to be valid and reduce bias in results is also essential. A high degree of heterogeneity, however can result in problems with the design of the trial.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers an array of traditional table games, including Blackjack and Roulette. The live studios of the company in Romania and Malta offer an authentic gambling experience for customers and offer a full suite of virtual betting options. The company has also created numerous interactive game shows that make online gambling enjoyable. Some of these shows have live hosts, whereas others are hosted by celebrities from the industry.

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Legality

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The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they shouldn't be used in lieu for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace explanatory tests or if they should serve as a complement to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the decision-making process for policy and practice. They also proposed the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a practical trial, including the recruitment process, the design and delivery of the intervention, as well as the follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind, however, that the majority of these studies were conducted in primary care settings.