18.2 Major Histocompatibility Complexes And Antigen-Presenting Cells - Microbiology > 자유게시판

Macrophages and dendritic cells use similar mechanisms for processing and presentation of antigens and their epitopes in affiliation with MHC II; B cells use considerably completely different mechanisms that can be described further in B Lymphocytes and Humoral Immunity. For now, we will concentrate on the steps of the method as they pertain to dendritic cells. After a dendritic cell recognizes and attaches to a pathogen cell, the pathogen is internalized by phagocytosis and is initially contained inside a phagosome. Lysosomes containing antimicrobial enzymes and chemicals fuse with the phagosome to create a phagolysosome, the place degradation of the pathogen for antigen processing begins. APCs do not present all doable epitopes to T cells; only a number of essentially the most antigenic or immunodominant epitopes are offered.

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