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Pragmatic trials are trials designed to provide information for real-world clinical practice. They are typically focused on the practical aspects of research design, like the recruitment and consent process as well as adherence to the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized a variety of investigators and had participants from different geographic areas. This kind of heterogeneity is essential for pragmatic trials to be valid and helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. Usually, they are requested by practitioners and 프라그마틱 무료스핀 policymakers to inform their decisions. They can also be used to determine the cause-effect relationship of an intervention with its outcomes. However, they should not be used to substitute for the use of explanation studies.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate a physiological or clinical hypothesis, and pragmatic trials that inform policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study that includes the recruitment, design, and delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is a sign that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. However, it is important to note that the majority of these studies were conducted in primary care settings.